Homo sapiens Protein: VCL
InnateDB Protein IDBP-78930.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VCL
Protein Name vinculin
Synonyms CMD1W; CMH15; HEL114; MV; MVCL;
Species Homo sapiens
Ensembl Protein ENSP00000361841
InnateDB Gene IDBG-78928 (VCL)
Protein Structure
UniProt Annotation
Function Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269PubMed:20484056}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:18439753}. Cell junction, adherens junction {ECO:0000269PubMed:18439753}. Cell membrane {ECO:0000269PubMed:18439753}; Peripheral membrane protein {ECO:0000269PubMed:18439753}; Cytoplasmic side {ECO:0000269PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.
Disease Associations Cardiomyopathy, dilated 1W (CMD1W) [MIM:611407]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:11815424, ECO:0000269PubMed:16236538}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, familial hypertrophic 15 (CMH15) [MIM:613255]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:16712796}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Metavinculin is muscle-specific.
Number of Interactions This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 213 [view]
Protein-Protein 212 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002162 dystroglycan binding
GO:0003779 actin binding
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
GO:0051015 actin filament binding
Biological Process
GO:0002009 morphogenesis of an epithelium
GO:0002576 platelet degranulation
GO:0006928 cellular component movement
GO:0006936 muscle contraction
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007596 blood coagulation
GO:0030032 lamellipodium assembly
GO:0030168 platelet activation
GO:0030336 negative regulation of cell migration
GO:0034333 adherens junction assembly
GO:0034394 protein localization to cell surface
GO:0043297 apical junction assembly
GO:0090136 epithelial cell-cell adhesion
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0005911 cell-cell junction
GO:0005912 adherens junction
GO:0005913 cell-cell adherens junction
GO:0005925 focal adhesion
GO:0015629 actin cytoskeleton
GO:0030055 cell-substrate junction
GO:0043034 costamere
GO:0043234 protein complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
InterPro IPR006077 Vinculin/alpha-catenin
IPR017997 Vinculin
PFAM PF01044
Post-translational Modifications
SwissProt P18206
PhosphoSite PhosphoSite-P18206
UniProt Splice Variant
Entrez Gene 7414
UniGene Hs.643896
RefSeq NP_003364
OMIM 193065
HPRD 01900
EMBL AL596247 AL731576 BC039174 BX537994 CH471083 L04933 M33308 S87175 S87178 S87180 S87218 S87223
GenPept AAA61271 AAA61283 AAB21656 AAB21657 AAH39174 CAD97952 CAI13972 CAI39673 EAW54550 EAW54551