InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VCL

Summary

InnateDB Protein

IDBP-78932.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VCL

Protein Name

vinculin

Synonyms

CMD1W; CMH15; HEL114; MV; MVCL;

Species

Homo sapiens

Ensembl Protein

ENSP00000211998

InnateDB Gene

IDBG-78928 (VCL)

Protein Structure

UniProt Annotation

Function

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell- surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. {ECO:0000269PubMed:20484056}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:18439753}. Cell junction, adherens junction {ECO:0000269PubMed:18439753}. Cell membrane {ECO:0000269PubMed:18439753}; Peripheral membrane protein {ECO:0000269PubMed:18439753}; Cytoplasmic side {ECO:0000269PubMed:18439753}. Cell junction, focal adhesion {ECO:0000269PubMed:18439753}. Note=Cytoplasmic face of adhesion plaques. Recruitment to cell-cell junctions occurs in a myosin II- dependent manner. Interaction with CTNNB1 is necessary for its localization to the cell-cell junctions (By similarity). Colocalizes with LIMD1 in the focal adhesions. {ECO:0000250}.

Disease Associations

Cardiomyopathy, dilated 1W (CMD1W) [MIM:611407]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269PubMed:11815424, ECO:0000269PubMed:16236538}. Note=The disease is caused by mutations affecting the gene represented in this entry.Cardiomyopathy, familial hypertrophic 15 (CMH15) [MIM:613255]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269PubMed:16712796}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Metavinculin is muscle-specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	213 [view]
Protein-Protein	212 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002162	dystroglycan binding
GO:0003779	actin binding
GO:0005198	structural molecule activity
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0045294	alpha-catenin binding
GO:0045296	cadherin binding
GO:0051015	actin filament binding

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0002576	platelet degranulation
GO:0006928	cellular component movement
GO:0006936	muscle contraction
GO:0007155	cell adhesion
GO:0007160	cell-matrix adhesion
GO:0007596	blood coagulation
GO:0030032	lamellipodium assembly
GO:0030168	platelet activation
GO:0030334	regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0034333	adherens junction assembly
GO:0034394	protein localization to cell surface
GO:0043297	apical junction assembly
GO:0090136	epithelial cell-cell adhesion

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005912	adherens junction
GO:0005913	cell-cell adherens junction
GO:0005916	fascia adherens
GO:0005925	focal adhesion
GO:0015629	actin cytoskeleton
GO:0030055	cell-substrate junction
GO:0043034	costamere
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome