InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: WDR12

Summary

InnateDB Protein

IDBP-78960.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

WDR12

Protein Name

WD repeat domain 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000261015

InnateDB Gene

IDBG-78958 (WDR12)

Protein Structure

UniProt Annotation

Function

Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. {ECO:0000255HAMAP-Rule:MF_03029, ECO:0000269PubMed:16043514, ECO:0000269PubMed:17353269}.

Subcellular Localization

Nucleus, nucleolus. Nucleus, nucleoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	37 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0043021	ribonucleoprotein complex binding

Biological Process

GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466	maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219	Notch signaling pathway
GO:0008283	cell proliferation
GO:0042273	ribosomal large subunit biogenesis