InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AP3M1

Summary

InnateDB Protein

IDBP-79009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AP3M1

Protein Name

adaptor-related protein complex 3, mu 1 subunit

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000347408

InnateDB Gene

IDBG-79007 (AP3M1)

Protein Structure

UniProt Annotation

Function

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

Subcellular Localization

Golgi apparatus. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	20 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0017137	Rab GTPase binding

Biological Process

GO:0006622	protein targeting to lysosome
GO:0006810	transport
GO:0006886	intracellular protein transport
GO:0008089	anterograde axon cargo transport
GO:0016192	vesicle-mediated transport
GO:0048490	anterograde synaptic vesicle transport

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005794	Golgi apparatus
GO:0030131	clathrin adaptor complex
GO:0030659	cytoplasmic vesicle membrane

Protein Structure and Domains

PDB ID

InterPro

IPR001392 Clathrin adaptor, mu subunit
IPR008968 Clathrin adaptor, mu subunit, C-terminal
IPR011012 Longin-like domain
IPR022775 AP complex, mu/sigma subunit
IPR028565 Mu homology domain

PFAM

PF00928
PF01217

PRINTS

PR00314

PIRSF

PIRSF005992

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt