Version 5.4
Homo sapiens Protein: SAMD8
Summary
InnateDB Protein IDBP-79224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SAMD8
Protein Name sterile alpha motif domain containing 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361775
InnateDB Gene IDBG-79222 (SAMD8)
Protein Structure
UniProt Annotation
Function Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway. {ECO:0000269PubMed:19506037}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:19506037}; Multi-pass membrane protein {ECO:0000269PubMed:19506037}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006686 sphingomyelin biosynthetic process
GO:0046513 ceramide biosynthetic process
GO:2000303 regulation of ceramide biosynthetic process
Cellular Component
GO:0016021 integral component of membrane
GO:0030176 integral component of endoplasmic reticulum membrane
Protein Structure and Domains
PDB ID
InterPro IPR001660 Sterile alpha motif domain
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1
PFAM PF00536
PRINTS
PIRSF
SMART SM00454
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q96LT4
TrEMBL Q5JSC9
UniProt Splice Variant
Entrez Gene 142891
UniGene Hs.743724
RefSeq
HUGO HGNC:26320
OMIM 611575
CCDS
HPRD 18014
IMGT
EMBL AK057811 AL392111 BC080593 BX280496 CH471083
GenPept AAH80593 BAB71586 CAI40906 CAI40909 EAW54566 EAW54567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca