InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NCOA3

Summary

InnateDB Protein

IDBP-79745.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NCOA3

Protein Name

nuclear receptor coactivator 3

Synonyms

ACTR; AIB-1; AIB1; bHLHe42; CAGH16; CTG26; KAT13B; pCIP; RAC3; SRC-3; SRC3; TNRC14; TNRC16; TRAM-1;

Species

Homo sapiens

Ensembl Protein

ENSP00000361066

InnateDB Gene

IDBG-79741 (NCOA3)

Protein Structure

UniProt Annotation

Function

Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity. Also involved in the coactivation of the NF-kappa-B pathway via its interaction with the NFKB1 subunit.

Subcellular Localization

Cytoplasm. Nucleus. Note=Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.

Disease Associations

Tissue Specificity

Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 174 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	174 [view]
Protein-Protein	154 [view]
Protein-DNA	9 [view]
Protein-RNA	1 [view]
DNA-DNA	10 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0035257	nuclear hormone receptor binding
GO:0046966	thyroid hormone receptor binding
GO:0046983	protein dimerization activity
GO:0047485	protein N-terminus binding
GO:0050681	androgen receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0010628	positive regulation of gene expression
GO:0016573	histone acetylation
GO:0030521	androgen receptor signaling pathway
GO:0035264	multicellular organism growth
GO:0035624	receptor transactivation
GO:0045618	positive regulation of keratinocyte differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048589	developmental growth
GO:0060068	vagina development
GO:0060713	labyrinthine layer morphogenesis
GO:0060744	mammary gland branching involved in thelarche
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR009110 Nuclear receptor coactivator, interlocking
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR013767 PAS fold
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR014935 Steroid receptor coactivator
IPR017426 Nuclear receptor coactivator

PFAM

PF13188
PF13426
PF00010
PF00989
PF08815
PF08832

PRINTS

PIRSF

PIRSF038181

SMART

SM00091
SM00353

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt