InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RGS12

Summary

InnateDB Protein

IDBP-7995.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RGS12

Protein Name

regulator of G-protein signaling 12

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000342133

InnateDB Gene

IDBG-7983 (RGS12)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form.Isoform 5: Behaves as a cell cycle-dependent transcriptional repressor, promoting inhibition of S-phase DNA synthesis.

Subcellular Localization

Nucleus {ECO:0000269PubMed:10869340}.Isoform 5: Nucleus matrix {ECO:0000269PubMed:12024043}. Note=Also localized to discrete nuclear foci that are distinct from sites of RNA processing, PML nuclear bodies, and PcG domains.

Disease Associations

Tissue Specificity

Isoform 3 is brain specific.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005096	GTPase activator activity
GO:0030695	GTPase regulator activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007165	signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0035556	intracellular signal transduction
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0000794	condensed nuclear chromosome
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000342 Regulator of G protein signalling domain
IPR003109 GoLoco motif
IPR003116 Raf-like Ras-binding
IPR016137 Regulator of G protein signalling superfamily
IPR029071 Ubiquitin-related domain

PFAM

PF00615
PF02188
PF02196

PRINTS

PR01301

PIRSF

SMART

SM00390
SM00455
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt