Version 5.4
Homo sapiens Protein: SPAG16
Summary
InnateDB Protein IDBP-80083.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPAG16
Protein Name sperm associated antigen 16
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332592
InnateDB Gene IDBG-80075 (SPAG16)
Protein Structure
UniProt Annotation
Function Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Note=Detected on the sperm flagellum axoneme. Detected in the central apparatus of the axoneme. Colocalizes with SPAG6 on microtubules (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 1 is detected in testis. Isoform 4 is detected in testis and brain, and at lower levels in kidney, heart, pancreas, thyroid, ovary, adrenal gland, spinal cord, trachea and liver. {ECO:0000269PubMed:11867345, ECO:0000269PubMed:12391165}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0007283 spermatogenesis
GO:0042384 cilium assembly
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
Protein Structure and Domains
PDB ID
InterPro IPR001680 WD40 repeat
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N0X2
PhosphoSite PhosphoSite-Q8N0X2
TrEMBL Q53TL7
UniProt Splice Variant
Entrez Gene 79582
UniGene Hs.743365
RefSeq NP_078808
HUGO HGNC:23225
OMIM 612173
CCDS CCDS2396
HPRD 18089
IMGT
EMBL AC008169 AC009964 AC024246 AC079610 AC092618 AC096565 AC107218 AF310672 AF426740 AF490390 AK026377 AK095036 AL832962 BC009614 BC067756 BC100282 CR457359 CR749477
GenPept AAH09614 AAH67756 AAI00283 AAM63956 AAM97147 AAN63530 AAX93063 AAX93092 AAX93125 AAX93264 AAY14888 AAY24171 AAY24242 BAB15466 BAC04481 CAG33640 CAH18307 CAH56274

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca