InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BARD1

Summary

InnateDB Protein

IDBP-80115.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BARD1

Protein Name

BRCA1 associated RING domain 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000260947

InnateDB Gene

IDBG-80113 (BARD1)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage. {ECO:0000269PubMed:12890688, ECO:0000269PubMed:14976165, ECO:0000269PubMed:20351172}.

Subcellular Localization

Nucleus. Note=During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 314 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	314 [view]
Protein-Protein	308 [view]
Protein-DNA	5 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019900	kinase binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001894	tissue homeostasis
GO:0006281	DNA repair
GO:0006974	cellular response to DNA damage stimulus
GO:0007050	cell cycle arrest
GO:0016567	protein ubiquitination
GO:0031441	negative regulation of mRNA 3'-end processing
GO:0042325	regulation of phosphorylation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045732	positive regulation of protein catabolic process
GO:0046826	negative regulation of protein export from nucleus
GO:0085020	protein K6-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0031436	BRCA1-BARD1 complex
GO:0043231	intracellular membrane-bounded organelle
GO:0070531	BRCA1-A complex