Version 5.4
Homo sapiens Protein: RHBDL1
Summary
InnateDB Protein IDBP-8023.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RHBDL1
Protein Name rhomboid, veinlet-like 1 (Drosophila)
Synonyms RHBDL; RRP;
Species Homo sapiens
Ensembl Protein ENSP00000219551
InnateDB Gene IDBG-8019 (RHBDL1)
Protein Structure
UniProt Annotation
Function May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. {ECO:0000250}.
Subcellular Localization Membrane; Multi-pass membrane protein.
Disease Associations
Tissue Specificity Detected in heart, brain, skeletal muscle and kidney.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017213 Peptidase S54, rhomboid, metazoan
IPR022764 Peptidase S54, rhomboid domain
PFAM PF01694
PRINTS
PIRSF PIRSF037470
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75783
PhosphoSite PhosphoSite-O75783
TrEMBL
UniProt Splice Variant
Entrez Gene 9028
UniGene Hs.137572
RefSeq XP_005255723
HUGO HGNC:10007
OMIM 603264
CCDS
HPRD 07050
IMGT
EMBL AE006464 AJ272344 BC120874 BC120875 CH471112 Y17108 Z92544
GenPept AAI20875 AAI20876 AAK61241 CAA76629 CAC00640 CAM26349 CAM26350 EAW85760

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca