Homo sapiens Protein: FN1 | |||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||
InnateDB Protein | IDBP-80243.7 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | FN1 | ||||||||||||||||||||||||||
Protein Name | fibronectin 1 | ||||||||||||||||||||||||||
Synonyms | CIG; ED-B; FINC; FN; FNZ; GFND; GFND2; LETS; MSF; | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Protein | ENSP00000323534 | ||||||||||||||||||||||||||
InnateDB Gene | IDBG-80237 (FN1) | ||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||
Function | Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts.Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling. | ||||||||||||||||||||||||||
Subcellular Localization | Secreted, extracellular space, extracellular matrix. | ||||||||||||||||||||||||||
Disease Associations | Glomerulopathy with fibronectin deposits 2 (GFND2) [MIM:601894]: Genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. {ECO:0000269PubMed:18268355}. Note=The disease is caused by mutations affecting the gene represented in this entry. | ||||||||||||||||||||||||||
Tissue Specificity | Plasma FN (soluble dimeric form) is secreted by hepatocytes. Cellular FN (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Ugl-Y1, Ugl-Y2 and Ugl-Y3 are found in urine. {ECO:0000269PubMed:17614963, ECO:0000269PubMed:3584091}. | ||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 758 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||
InterPro |
IPR000083
Fibronectin, type I IPR000562 Fibronectin, type II, collagen-binding IPR003961 Fibronectin, type III IPR013806 Kringle-like fold |
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PFAM |
PF00039
PF00040 PF00041 PF01108 |
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PRINTS | |||||||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||||||
SMART |
SM00058
SM00059 SM00060 |
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TIGRFAMs | |||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | P02751 | ||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-P02751 | ||||||||||||||||||||||||||
TrEMBL | Q9H382 | ||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 2335 | ||||||||||||||||||||||||||
UniGene | Hs.660195 | ||||||||||||||||||||||||||
RefSeq | XP_005246456 | ||||||||||||||||||||||||||
HUGO | HGNC:3778 | ||||||||||||||||||||||||||
OMIM | 135600 | ||||||||||||||||||||||||||
CCDS | |||||||||||||||||||||||||||
HPRD | 00626 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AB191261 AB209840 AC012462 AC073284 AF130095 AF312399 AJ276395 AJ320525 AJ320526 AJ320527 AJ535086 AJ849445 AL832202 BC005858 BC117176 BC143763 BT006856 BX537590 BX538017 BX538018 BX538045 BX640608 BX640731 BX640875 BX640920 CH471063 CR749281 CR749316 CR749317 EF550130 M10905 M12549 M14059 M15801 M18177 M18178 M18179 M27589 U41850 U42404 U42455 U42456 U42457 U42458 U42592 U42593 U42594 X02761 X04530 X07717 X07718 | ||||||||||||||||||||||||||
GenPept | AAA52461 AAA52462 AAA52463 AAA52465 AAA53376 AAA58483 AAD00014 AAD00015 AAD00017 AAD00018 AAD00019 AAD04751 AAD09448 AAD09449 AAD09450 AAG30571 AAG35520 AAH05858 AAI17177 AAI43764 AAP35502 AAX76513 AAY24063 ABR68534 BAD52437 BAD93077 CAA26536 CAB52436 CAB52437 CAC20427 CAC86914 CAC86915 CAC86916 CAD59389 CAD91166 CAD97791 CAD97964 CAD97965 CAD97984 CAE45714 CAE45847 CAE45932 CAE45958 CAH18136 CAH18171 CAH18172 CAH60958 EAW70536 | ||||||||||||||||||||||||||