InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PTPN3

Summary

InnateDB Protein

IDBP-80260.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTPN3

Protein Name

protein tyrosine phosphatase, non-receptor type 3

Synonyms

PTP-H1; PTPH1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363667

InnateDB Gene

IDBG-80258 (PTPN3)

Protein Structure

UniProt Annotation

Function

May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001784	phosphotyrosine binding
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity
GO:0051117	ATPase binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0045930	negative regulation of mitotic cell cycle
GO:0051045	negative regulation of membrane protein ectodomain proteolysis
GO:0097421	liver regeneration

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0009898	cytoplasmic side of plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000299 FERM domain
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR000798 Ezrin/radixin/moesin like
IPR001478 PDZ domain
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR012151 Protein-tyrosine phosphatase, non-receptor type-3, -4
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR029021 Protein-tyrosine phosphatase-like
IPR029071 Ubiquitin-related domain

PFAM