Homo sapiens Protein: TXN
Summary
InnateDB Protein IDBP-80365.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN
Protein Name thioredoxin
Synonyms TRDX; TRX; TRX1;
Species Homo sapiens
Ensembl Protein ENSP00000363639
InnateDB Gene IDBG-80361 (TXN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 75 experimentally validated interaction(s) in this database.
Experimentally validated
Total 75 [view]
Protein-Protein 74 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006662 glycerol ether metabolic process
GO:0006928 cellular component movement
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0009314 response to radiation
GO:0015949 nucleobase-containing small molecule interconversion
GO:0033158 regulation of protein import into nucleus, translocation
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0043388 positive regulation of DNA binding
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045454 cell redox homeostasis
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P10599
PhosphoSite PhosphoSite-P10599
TrEMBL
UniProt Splice Variant
Entrez Gene 7295
UniGene Hs.615540
RefSeq NP_001231867
HUGO HGNC:12435
OMIM 187700
CCDS CCDS59139
HPRD 01761
IMGT
EMBL AF065241 AF276919 AF313911 AF548001 AK289508 AL158158 AY004872 BC003377 BC054866 CH471105 CR407665 J04026 X54539 X54540 X54541 X77584
GenPept AAA74596 AAC17430 AAF86466 AAF87085 AAG34699 AAH03377 AAH54866 AAN33187 BAF82197 CAA38410 CAA54687 CAG28593 CAI14066 CAI14067 EAW59059 EAW59060