Version 5.4
Homo sapiens Protein: FAM213A
Summary
InnateDB Protein IDBP-80491.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM213A
Protein Name chromosome 10 open reading frame 58
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361261
InnateDB Gene IDBG-80487 (FAM213A)
Protein Structure
UniProt Annotation
Function Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. {ECO:0000269PubMed:19951071}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:19951071}.
Disease Associations
Tissue Specificity Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs). {ECO:0000269PubMed:19951071}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016209 antioxidant activity
Biological Process
GO:0045670 regulation of osteoclast differentiation
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR012336 Thioredoxin-like fold
PFAM PF13098
PF13192
PF13462
PF13905
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9BRX8
PhosphoSite PhosphoSite-Q9BRX8
TrEMBL
UniProt Splice Variant
Entrez Gene 84293
UniGene Hs.500333
RefSeq NP_001230711
HUGO HGNC:28651
OMIM
CCDS CCDS7368
HPRD 12580
IMGT
EMBL AC021028 AF305824 AK074643 AK075447 AK315440 AY359059 BC005871
GenPept AAH05871 AAK55527 AAQ89418 BAC11108 BAC11627 BAG37828

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca