InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRG3

Summary

InnateDB Protein

IDBP-80648.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRG3

Protein Name

neuregulin 3

Synonyms

HRG3; pro-NRG3;

Species

Homo sapiens

Ensembl Protein

ENSP00000361214

InnateDB Gene

IDBG-80642 (NRG3)

Protein Structure

UniProt Annotation

Function

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269PubMed:16478787, ECO:0000269PubMed:9275162}.

Subcellular Localization

Pro-neuregulin-3, membrane-bound isoform: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.Neuregulin-3: Secreted {ECO:0000250}.Isoform 3: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.

Disease Associations

Tissue Specificity

Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0030297	transmembrane receptor protein tyrosine kinase activator activity
GO:0030971	receptor tyrosine kinase binding

Biological Process

GO:0001558	regulation of cell growth
GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007389	pattern specification process
GO:0009790	embryo development
GO:0030879	mammary gland development
GO:0035556	intracellular signal transduction
GO:0060596	mammary placode formation