InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PLCG1

Summary

InnateDB Protein

IDBP-806632.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCG1

Protein Name

phospholipase C, gamma 1

Synonyms

NCKAP3; PLC-II; PLC1; PLC148; PLCgamma1;

Species

Homo sapiens

Ensembl Protein

ENSP00000476432

InnateDB Gene

IDBG-75238 (PLCG1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 237 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	237 [view]
Protein-Protein	236 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0016042	lipid catabolic process
GO:0035556	intracellular signal transduction

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain

PFAM

PF00168
PF00387

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00149

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt