InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRYAB

Summary

InnateDB Protein

IDBP-807004.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRYAB

Protein Name

crystallin, alpha B

Synonyms

CMD1II; CRYA2; CTPP2; CTRCT16; HEL-S-101; HSPB5; MFM2;

Species

Homo sapiens

Ensembl Protein

ENSP00000483554

InnateDB Gene

IDBG-71081 (CRYAB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005212	structural constituent of eye lens
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006936	muscle contraction
GO:0010941	regulation of cell death
GO:0032387	negative regulation of intracellular transport
GO:0043066	negative regulation of apoptotic process
GO:0051260	protein homooligomerization
GO:0071480	cellular response to gamma radiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001436 Alpha crystallin/Heat shock protein
IPR002068 Alpha crystallin/Hsp20 domain
IPR003090 Alpha-crystallin, N-terminal
IPR008978 HSP20-like chaperone

PFAM

PF00011
PF00525

PRINTS

PR00299

PIRSF

PIRSF036514

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt