InnateDB Protein
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IDBP-80751.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TCEAL1
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Protein Name
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transcription elongation factor A (SII)-like 1
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Synonyms
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p21; pp21; SIIR; WEX9;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000361709
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InnateDB Gene
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IDBG-80749 (TCEAL1)
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Protein Structure
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Function |
May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines. {ECO:0000269PubMed:10051408}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003700
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sequence-specific DNA binding transcription factor activity
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006351
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transcription, DNA-templated
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Cellular Component |
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PDB ID |
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InterPro |
IPR021156
Transcription elongation factor A-like/Brain expressed X-linked-like
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PFAM |
PF04538
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q15170
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PhosphoSite |
PhosphoSite-Q15170
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
9338
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UniGene |
Hs.95243
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RefSeq |
NP_001006641
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HUGO |
HGNC:11616
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OMIM |
300237
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CCDS |
CCDS35358
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HPRD |
02211
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IMGT |
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EMBL |
AF095906
AL049610
BC000809
M99701
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GenPept |
AAA60149
AAD17840
AAH00809
CAB55700
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