Version 5.4
Homo sapiens Protein: TCEAL1
Summary
InnateDB Protein IDBP-80755.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCEAL1
Protein Name transcription elongation factor A (SII)-like 1
Synonyms p21; pp21; SIIR; WEX9;
Species Homo sapiens
Ensembl Protein ENSP00000361708
InnateDB Gene IDBG-80749 (TCEAL1)
Protein Structure
UniProt Annotation
Function May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context- dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines. {ECO:0000269PubMed:10051408}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15170
PhosphoSite PhosphoSite-Q15170
TrEMBL
UniProt Splice Variant
Entrez Gene 9338
UniGene Hs.95243
RefSeq NP_004771
HUGO HGNC:11616
OMIM 300237
CCDS CCDS35358
HPRD 02211
IMGT
EMBL AF095906 AL049610 BC000809 M99701
GenPept AAA60149 AAD17840 AAH00809 CAB55700

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca