InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OAS2

Summary

InnateDB Protein

IDBP-808625.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OAS2

Protein Name

2'-5'-oligoadenylate synthetase 2, 69/71kDa

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000483679

InnateDB Gene

IDBG-58392 (OAS2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001730	2'-5'-oligoadenylate synthetase activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006486	protein glycosylation
GO:0006955	immune response
GO:0009615	response to virus
GO:0018377	protein myristoylation
GO:0019221	cytokine-mediated signaling pathway
GO:0051607	defense response to virus
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0060337	type I interferon signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR002934 Nucleotidyl transferase domain
IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR018952 2\'-5\'-oligoadenylate synthetase 1, domain 2/C-terminal

PFAM

PF01909
PF10421

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

4939

UniGene

RefSeq

HUGO

HGNC:8087

OMIM

603350

CCDS

HPRD

IMGT

EMBL

AC004551 AK292796 BC023637 BC049215 CH471054 M87284 M87434

GenPept

AAA60606 AAA60607 AAH23637 AAH49215 BAF85485 EAW98027