InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRB3

Summary

InnateDB Protein

IDBP-810159.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB3

Protein Name

adrenoceptor beta 3

Synonyms

BETA3AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000480325

InnateDB Gene

IDBG-17239 (ADRB3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0005515	protein binding
GO:0015052	beta3-adrenergic receptor activity
GO:0042803	protein homodimerization activity
GO:0051380	norepinephrine binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0043410	positive regulation of MAPK cascade
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000681 Beta 3 adrenoceptor
IPR002232 5-Hydroxytryptamine 6 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00563
PR01102
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite