InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BTK

Summary

InnateDB Protein

IDBP-811243.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BTK

Protein Name

Bruton agammaglobulinemia tyrosine kinase

Synonyms

AGMX1; AT; ATK; BPK; IMD1; PSCTK1; XLA;

Species

Homo sapiens

Ensembl Protein

ENSP00000483570

InnateDB Gene

IDBG-79651 (BTK)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 106 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	106 [view]
Protein-Protein	104 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004715	non-membrane spanning protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002250	adaptive immune response
GO:0002553	histamine secretion by mast cell
GO:0002721	regulation of B cell cytokine production
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002902	regulation of B cell apoptotic process
GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007498	mesoderm development
GO:0010033	response to organic substance
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019722	calcium-mediated signaling
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034614	cellular response to reactive oxygen species
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0042113	B cell activation
GO:0045087	innate immune response (InnateDB)
GO:0045579	positive regulation of B cell differentiation
GO:0046777	protein autophosphorylation
GO:0048469	cell maturation
GO:0050853	B cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0071226	cellular response to molecule of fungal origin
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0031410	cytoplasmic vesicle
GO:0042629	mast cell granule
GO:0043231	intracellular membrane-bounded organelle
GO:0045121	membrane raft
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM