InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UGCG

Summary

InnateDB Protein

IDBP-81138.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGCG

Protein Name

UDP-glucose ceramide glucosyltransferase

Synonyms

GCS; GLCT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363397

InnateDB Gene

IDBG-81136 (UGCG)

Protein Structure

UniProt Annotation

Function

Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. May also serve as a "flippase". {ECO:0000269PubMed:8643456}.

Subcellular Localization

Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Found in all tissues examined. {ECO:0000269PubMed:8643456}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008120	ceramide glucosyltransferase activity

Biological Process

GO:0006665	sphingolipid metabolic process
GO:0006679	glucosylceramide biosynthetic process
GO:0006687	glycosphingolipid metabolic process
GO:0006688	glycosphingolipid biosynthetic process
GO:0008544	epidermis development
GO:0044281	small molecule metabolic process