InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MINPP1

Summary

InnateDB Protein

IDBP-81293.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MINPP1

Protein Name

multiple inositol-polyphosphate phosphatase 1

Synonyms

HIPER1; MINPP2; MIPP;

Species

Homo sapiens

Ensembl Protein

ENSP00000361062

InnateDB Gene

IDBG-81289 (MINPP1)

Protein Structure

UniProt Annotation

Function

Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3-bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3- phosphoglycerate. May play a role in bone development (endochondral ossification). {ECO:0000269PubMed:18413611}.

Subcellular Localization

Endoplasmic reticulum lumen {ECO:0000255PROSITE-ProRule:PRU10138}.

Disease Associations

Note=Defects in MINPP1 may be involved in follicular thyroid tumors development.

Tissue Specificity

Widely expressed with highest levels in kidney, liver and placenta. {ECO:0000269PubMed:9923613}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003993	acid phosphatase activity
GO:0008969	phosphohistidine phosphatase activity
GO:0034417	bisphosphoglycerate 3-phosphatase activity
GO:0052826	inositol hexakisphosphate 2-phosphatase activity

Biological Process

GO:0001503	ossification
GO:0006797	polyphosphate metabolic process
GO:0016311	dephosphorylation
GO:0030282	bone mineralization
GO:0043647	inositol phosphate metabolic process
GO:0044281	small molecule metabolic process