InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: G6PD

Summary

InnateDB Protein

IDBP-813661.1

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

G6PD

Protein Name

glucose-6-phosphate dehydrogenase

Synonyms

G6PD1;

Species

Homo sapiens

Ensembl Protein

ENSP00000483686

InnateDB Gene

IDBG-91750 (G6PD)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	42 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004345	glucose-6-phosphate dehydrogenase activity
GO:0005515	protein binding
GO:0005536	glucose binding
GO:0042803	protein homodimerization activity
GO:0050661	NADP binding

Biological Process

GO:0001816	cytokine production
GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006098	pentose-phosphate shunt
GO:0006629	lipid metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006739	NADP metabolic process
GO:0006740	NADPH regeneration
GO:0006749	glutathione metabolic process
GO:0009051	pentose-phosphate shunt, oxidative branch
GO:0010734	negative regulation of protein glutathionylation
GO:0019322	pentose biosynthetic process
GO:0021762	substantia nigra development
GO:0034599	cellular response to oxidative stress
GO:0043249	erythrocyte maturation
GO:0044281	small molecule metabolic process
GO:0046390	ribose phosphate biosynthetic process
GO:0051156	glucose 6-phosphate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009898	cytoplasmic side of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR001282 Glucose-6-phosphate dehydrogenase
IPR022674 Glucose-6-phosphate dehydrogenase, NAD-binding
IPR022675 Glucose-6-phosphate dehydrogenase, C-terminal

PFAM

PF00479
PF02781

PRINTS

PR00079

PIRSF

PIRSF000110

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt