InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC31A1

Summary

InnateDB Protein

IDBP-81538.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC31A1

Protein Name

solute carrier family 31 (copper transporters), member 1

Synonyms

COPT1; CTR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363329

InnateDB Gene

IDBG-81536 (SLC31A1)

Protein Structure

UniProt Annotation

Function

High-affinity, saturable copper transporter involved in dietary copper uptake. {ECO:0000269PubMed:11734551}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane in intestinal epithelial cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005375	copper ion transmembrane transporter activity
GO:0005515	protein binding
GO:0015088	copper uptake transmembrane transporter activity

Biological Process

GO:0006825	copper ion transport
GO:0006855	drug transmembrane transport
GO:0006878	cellular copper ion homeostasis
GO:0015677	copper ion import
GO:0035434	copper ion transmembrane transport
GO:0055085	transmembrane transport
GO:0072719	cellular response to cisplatin
GO:1902861	copper ion import into cell

Cellular Component

GO:0005737	cytoplasm
GO:0005770	late endosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body
GO:0055037	recycling endosome