InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPEG

Summary

InnateDB Protein

IDBP-81744.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPEG

Protein Name

SPEG complex locus

Synonyms

APEG-1; APEG1; BPEG; CNM5; SPEGalpha; SPEGbeta;

Species

Homo sapiens

Ensembl Protein

ENSP00000311684

InnateDB Gene

IDBG-81742 (SPEG)

Protein Structure

UniProt Annotation

Function

Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells.

Subcellular Localization

Isoform 3: Nucleus.

Disease Associations

Tissue Specificity

Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. {ECO:0000269PubMed:15185077, ECO:0000269PubMed:8663449}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0001701	in utero embryonic development
GO:0006468	protein phosphorylation
GO:0007517	muscle organ development
GO:0008285	negative regulation of cell proliferation
GO:0042692	muscle cell differentiation
GO:0055013	cardiac muscle cell development
GO:0060541	respiratory system development
GO:0072358	cardiovascular system development

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR003961 Fibronectin, type III
IPR007110 Immunoglobulin-like domain
IPR011009 Protein kinase-like domain
IPR013098 Immunoglobulin I-set
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00041
PF01108
PF07679

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00408
SM00409
SM00060
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt