Version 5.4
Homo sapiens Protein: ATG4A
Summary
InnateDB Protein IDBP-81870.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATG4A
Protein Name ATG4 autophagy related 4 homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000361306
InnateDB Gene IDBG-81860 (ATG4A)
Protein Structure
UniProt Annotation
Function Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms. {ECO:0000269PubMed:12473658, ECO:0000269PubMed:15169837, ECO:0000269PubMed:17347651, ECO:0000269PubMed:21177865, ECO:0000269PubMed:21245471, ECO:0000269PubMed:22302004}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed, at a low level, and the highest expression is observed in skeletal muscle and brain. Also detected in fetal liver. {ECO:0000269PubMed:12446702, ECO:0000269PubMed:15169837}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006914 autophagy
GO:0015031 protein transport
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005078 Peptidase C54
PFAM PF03416
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WYN0
PhosphoSite PhosphoSite-Q8WYN0
TrEMBL
UniProt Splice Variant
Entrez Gene 115201
UniGene Hs.8763
RefSeq NP_443168
HUGO HGNC:16489
OMIM 300663
CCDS CCDS14538
HPRD 06455
IMGT
EMBL AB066214 AJ320508 AJ320509 AJ504651 AK314429 AL031177 BC041862 BC061696 CH471120
GenPept AAH41862 AAH61696 BAB83889 BAG37044 CAC69076 CAC69077 CAD43218 CAI43137 CAI43138 CAI43141 CAI43142 EAX02689 EAX02691 EAX02693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca