InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSTF1

Summary

InnateDB Protein

IDBP-81880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSTF1

Protein Name

cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa

Synonyms

CstF-50; CstFp50;

Species

Homo sapiens

Ensembl Protein

ENSP00000217109

InnateDB Gene

IDBG-81876 (CSTF1)

Protein Structure

UniProt Annotation

Function

One of the multiple factors required for polyadenylation and 3'-end cleavage of mammalian pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	17 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage
GO:0006396	RNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0031124	mRNA 3'-end processing