InnateDB Protein
|
IDBP-81997.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
TFAP2C
|
Protein Name
|
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
|
Synonyms
|
AP2-GAMMA; ERF1; hAP-2g; TFAP2G;
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000201031
|
InnateDB Gene
|
IDBG-81995 (TFAP2C)
|
Protein Structure
|
|
Function |
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000269PubMed:11694877, ECO:0000269PubMed:24413532}.
|
Subcellular Localization |
Nucleus {ECO:0000269PubMed:24413532}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
|
Molecular Function |
Accession |
GO Term |
GO:0000977
|
RNA polymerase II regulatory region sequence-specific DNA binding
|
GO:0000980
|
RNA polymerase II distal enhancer sequence-specific DNA binding
|
GO:0000981
|
sequence-specific DNA binding RNA polymerase II transcription factor activity
|
GO:0001077
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
|
GO:0001078
|
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
|
GO:0003677
|
DNA binding
|
GO:0003700
|
sequence-specific DNA binding transcription factor activity
|
GO:0005515
|
protein binding
|
GO:0046983
|
protein dimerization activity
|
|
Biological Process |
GO:0000122
|
negative regulation of transcription from RNA polymerase II promoter
|
GO:0001829
|
trophectodermal cell differentiation
|
GO:0001942
|
hair follicle development
|
GO:0003334
|
keratinocyte development
|
GO:0006355
|
regulation of transcription, DNA-templated
|
GO:0006357
|
regulation of transcription from RNA polymerase II promoter
|
GO:0006366
|
transcription from RNA polymerase II promoter
|
GO:0007267
|
cell-cell signaling
|
GO:0008584
|
male gonad development
|
GO:0019827
|
stem cell maintenance
|
GO:0021877
|
forebrain neuron fate commitment
|
GO:0021987
|
cerebral cortex development
|
GO:0030154
|
cell differentiation
|
GO:0030718
|
germ-line stem cell maintenance
|
GO:0035019
|
somatic stem cell maintenance
|
GO:0043588
|
skin development
|
GO:0045682
|
regulation of epidermis development
|
GO:0045944
|
positive regulation of transcription from RNA polymerase II promoter
|
GO:0048733
|
sebaceous gland development
|
GO:0060598
|
dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis
|
GO:0060750
|
epithelial cell proliferation involved in mammary gland duct elongation
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
IPR008123
Transcription factor AP-2 gamma
IPR013854
Transcription factor AP-2, C-terminal
|
PFAM |
PF03299
|
PRINTS |
PR01751
PR01748
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q92754
|
PhosphoSite |
PhosphoSite-Q92754
|
TrEMBL |
B4DWK3
|
UniProt Splice Variant |
|
Entrez Gene |
7022
|
UniGene |
Hs.473152
|
RefSeq |
NP_003213
|
HUGO |
HGNC:11744
|
OMIM |
601602
|
CCDS |
CCDS13454
|
HPRD |
03361
|
IMGT |
|
EMBL |
AB041717
AJ315934
AK301572
AL121920
BC035664
BC051829
U85658
X95693
|
GenPept |
AAC51305
AAH35664
AAH51829
BAC11805
BAG63065
CAA64989
CAC10334
CAC86997
|
|
|