InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AKNA

Summary

InnateDB Protein

IDBP-82105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AKNA

Protein Name

AT-hook transcription factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000363201

InnateDB Gene

IDBG-82103 (AKNA)

Protein Structure

UniProt Annotation

Function

Transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. {ECO:0000269PubMed:11268217}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11268217}.

Disease Associations

Tissue Specificity

Predominantly expressed by lymphoid tissues. Highly expressed in the spleen, lymph nodes and peripheral blood leukocytes, expressed at lower level in the thymus. Mainly expressed by germinal center B-lymphocytes, a stage in which receptor and ligand interactions are crucial for B-lymphocyte maturation. Expressed by B- and T-lymphocytes, Natural killer cells and CD1a(+)CD14(-) but not CD1a(-)CD14(+) dendritic cells. Weakly or not expressed in fetal liver and in adult bone marrow. {ECO:0000269PubMed:11268217}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Biological Process

GO:0006351	transcription, DNA-templated
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter