InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RING1

Summary

InnateDB Protein

IDBP-82379.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RING1

Protein Name

ring finger protein 1

Synonyms

RING1A; RNF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363787

InnateDB Gene

IDBG-82377 (RING1)

Protein Structure

UniProt Annotation

Function

Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269PubMed:16359901}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:21282530}. Nucleus speckle {ECO:0000269PubMed:21282530}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 99 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	99 [view]
Protein-Protein	98 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0009952	anterior/posterior pattern specification
GO:0016574	histone ubiquitination
GO:0035518	histone H2A monoubiquitination
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048593	camera-type eye morphogenesis

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0001739	sex chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016607	nuclear speck
GO:0031519	PcG protein complex
GO:0035102	PRC1 complex