InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MARCH5

Summary

InnateDB Protein

IDBP-82452.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MARCH5

Protein Name

membrane-associated ring finger (C3HC4) 5

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000351813

InnateDB Gene

IDBG-82450 (MARCH5)

Protein Structure

UniProt Annotation

Function

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. {ECO:0000269PubMed:16874301, ECO:0000269PubMed:17606867, ECO:0000269PubMed:19741096, ECO:0000269PubMed:20103533}.

Subcellular Localization

Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note=Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301). {ECO:0000269PubMed:14722266, ECO:0000269PubMed:16874301}.

Disease Associations

Tissue Specificity

Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle. {ECO:0000269PubMed:16874301}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.

Experimentally validated
Total	31 [view]
Protein-Protein	30 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding
GO:0051020	GTPase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0045087	innate immune response (InnateDB)
GO:0051865	protein autoubiquitination
GO:0070585	protein localization to mitochondrion
GO:0090140	regulation of mitochondrial fission
GO:0090141	positive regulation of mitochondrial fission
GO:0090344	negative regulation of cell aging

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane