InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KIF11

Summary

InnateDB Protein

IDBP-82527.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KIF11

Protein Name

kinesin family member 11

Synonyms

EG5; HKSP; KNSL1; MCLMR; TRIP5;

Species

Homo sapiens

Ensembl Protein

ENSP00000260731

InnateDB Gene

IDBG-82525 (KIF11)

Protein Structure

UniProt Annotation

Function

Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays. {ECO:0000269PubMed:19001501}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:19001501}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269PubMed:19001501}.

Disease Associations

Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation (MCLMR) [MIM:152950]: An autosomal dominant disorder that involves an overlapping but variable spectrum of central nervous system and ocular developmental anomalies. Microcephaly ranges from mild to severe and is often associated with mild to moderate developmental delay and a characteristic facial phenotype with upslanting palpebral fissures, broad nose with rounded tip, long philtrum with thin upper lip, prominent chin, and prominent ears. Chorioretinopathy is the most common eye abnormality, but retinal folds, microphthalmia, and myopic and hypermetropic astigmatism have also been reported, and some individuals have no overt ocular phenotype. Congenital lymphedema, when present, is typically confined to the dorsa of the feet, and lymphoscintigraphy reveals the absence of radioactive isotope uptake from the webspaces between the toes. {ECO:0000269PubMed:22284827}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	23 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003777	microtubule motor activity
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0032403	protein complex binding

Biological Process

GO:0007018	microtubule-based movement
GO:0007051	spindle organization
GO:0007052	mitotic spindle organization
GO:0007067	mitotic nuclear division
GO:0007100	mitotic centrosome separation
GO:0007596	blood coagulation
GO:0008152	metabolic process
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0090307	spindle assembly involved in mitosis

Cellular Component

GO:0000922	spindle pole
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005829	cytosol
GO:0005871	kinesin complex
GO:0005874	microtubule
GO:0005876	spindle microtubule
GO:0016020	membrane