InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAK1

Summary

InnateDB Protein

IDBP-82946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAK1

Protein Name

BCL2-antagonist/killer 1

Synonyms

BAK; BAK-LIKE; BCL2L7; CDN1;

Species

Homo sapiens

Ensembl Protein

ENSP00000363591

InnateDB Gene

IDBG-82944 (BAK1)

Protein Structure

UniProt Annotation

Function

In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti- apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis. {ECO:0000269PubMed:17157251, ECO:0000269PubMed:8521816}.

Subcellular Localization

Mitochondrion membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	63 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031072	heat shock protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051087	chaperone binding
GO:0051400	BH domain binding

Biological Process

GO:0001776	leukocyte homeostasis
GO:0001782	B cell homeostasis
GO:0001783	B cell apoptotic process
GO:0001836	release of cytochrome c from mitochondria
GO:0001974	blood vessel remodeling
GO:0002262	myeloid cell homeostasis
GO:0002352	B cell negative selection
GO:0006915	apoptotic process
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007420	brain development
GO:0007568	aging
GO:0008053	mitochondrial fusion
GO:0008283	cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO:0009620	response to fungus
GO:0010046	response to mycotoxin
GO:0010225	response to UV-C
GO:0010248	establishment or maintenance of transmembrane electrochemical gradient
GO:0010332	response to gamma radiation
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0010629	negative regulation of gene expression
GO:0014070	response to organic cyclic compound
GO:0031018	endocrine pancreas development
GO:0031100	organ regeneration
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032471	negative regulation of endoplasmic reticulum calcium ion concentration
GO:0033137	negative regulation of peptidyl-serine phosphorylation
GO:0034644	cellular response to UV
GO:0035108	limb morphogenesis
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0042981	regulation of apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043496	regulation of protein homodimerization activity
GO:0043497	regulation of protein heterodimerization activity
GO:0044346	fibroblast apoptotic process
GO:0045471	response to ethanol
GO:0045862	positive regulation of proteolysis
GO:0046902	regulation of mitochondrial membrane permeability
GO:0048597	post-embryonic camera-type eye morphogenesis
GO:0048872	homeostasis of number of cells
GO:0051726	regulation of cell cycle
GO:0051881	regulation of mitochondrial membrane potential
GO:0060068	vagina development
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070242	thymocyte apoptotic process
GO:0071260	cellular response to mechanical stimulus
GO:0090200	positive regulation of release of cytochrome c from mitochondria
GO:0097190	apoptotic signaling pathway
GO:0097192	extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193	intrinsic apoptotic signaling pathway
GO:0097202	activation of cysteine-type endopeptidase activity
GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response
GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:1902262	apoptotic process involved in patterning of blood vessels

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0016020	membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0031966	mitochondrial membrane
GO:0046930	pore complex