InnateDB Protein
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IDBP-83214.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TH1L
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Protein Name
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TH1-like (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000342300
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InnateDB Gene
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IDBG-83212 (TH1L)
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Protein Structure
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Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269PubMed:10199401, ECO:0000269PubMed:12612062}.
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Subcellular Localization |
Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal and cardiac muscle, adrenal, thyroid, kidney and pancreas. {ECO:0000269PubMed:11030415, ECO:0000269PubMed:12612062}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
47
[view]
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Protein-Protein |
47
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006942
TH1 protein
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PFAM |
PF04858
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IXH7
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PhosphoSite |
PhosphoSite-Q8IXH7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
51497
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UniGene |
Hs.629101
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RefSeq |
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HUGO |
HGNC:15934
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OMIM |
605297
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CCDS |
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HPRD |
16096
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IMGT |
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EMBL |
AF161479
AJ238374
AJ238375
AJ238379
AK001316
AK023310
AK023927
AK293410
AL109840
BC014952
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GenPept |
AAF29094
AAH14952
BAA91618
BAB14519
BAB14729
BAG56917
CAB64337
CAB64339
CAB64373
CAC09368
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