InnateDB Protein
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IDBP-83519.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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STOM
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Protein Name
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stomatin
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Synonyms
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BND7; EPB7; EPB72;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000286713
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InnateDB Gene
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IDBG-83517 (STOM)
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Protein Structure
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Function |
Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
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Subcellular Localization |
Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
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Disease Associations |
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Tissue Specificity |
Detected in erythrocytes (at protein level). Widely expressed. {ECO:0000269PubMed:1547348, ECO:0000269PubMed:23219802}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
41
[view]
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Protein-Protein |
38
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0034765
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regulation of ion transmembrane transport
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GO:0051260
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protein homooligomerization
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GO:1901585
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regulation of acid-sensing ion channel activity
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Cellular Component |
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PDB ID |
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InterPro |
IPR001107
Band 7 protein
IPR001972
Stomatin family
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PFAM |
PF01145
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PRINTS |
PR00721
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PIRSF |
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SMART |
SM00244
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TIGRFAMs |
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Modification |
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SwissProt |
P27105
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PhosphoSite |
PhosphoSite-P27105
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TrEMBL |
B4E2V5
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UniProt Splice Variant |
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Entrez Gene |
2040
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UniGene |
Hs.253903
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RefSeq |
NP_004090
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HUGO |
HGNC:3383
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OMIM |
133090
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CCDS |
CCDS6830
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HPRD |
00585
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IMGT |
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EMBL |
AK304449
AL161784
AL359644
BC010703
BI603242
CH471090
CR542100
M81635
U33925
U33926
U33927
U33928
U33929
U33930
U33931
X60067
X85116
X85117
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GenPept |
AAA58432
AAC50296
AAH10703
BAG65267
CAA42671
CAA59436
CAG46897
CAH70728
CAH70729
CAH72706
CAH72707
EAW87493
EAW87494
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