InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STOM

Summary

InnateDB Protein

IDBP-83519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STOM

Protein Name

stomatin

Synonyms

BND7; EPB7; EPB72;

Species

Homo sapiens

Ensembl Protein

ENSP00000286713

InnateDB Gene

IDBG-83517 (STOM)

Protein Structure

UniProt Annotation

Function

Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.

Subcellular Localization

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Lipid-anchor; Cytoplasmic side. Melanosome. Cytoplasmic vesicle {ECO:0000250}. Note=Exposed on the cytoplasmic surface of the membrane. Associated with lipid rafts. Concentrates preferentially in plasma membrane protrusions and in a juxta-nuclear region which may represent Golgi-derived vesicles. Colocalizes with actin. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Disease Associations

Tissue Specificity

Detected in erythrocytes (at protein level). Widely expressed. {ECO:0000269PubMed:1547348, ECO:0000269PubMed:23219802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	38 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0034765	regulation of ion transmembrane transport
GO:0051260	protein homooligomerization
GO:1901585	regulation of acid-sensing ion channel activity

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0042470	melanosome
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome
GO:0072562	blood microparticle