InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPDEF

Summary

InnateDB Protein

IDBP-83612.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPDEF

Protein Name

SAM pointed domain containing ets transcription factor

Synonyms

bA375E1.3; PDEF;

Species

Homo sapiens

Ensembl Protein

ENSP00000363149

InnateDB Gene

IDBG-83610 (SPDEF)

Protein Structure

UniProt Annotation

Function

May function as an androgen-independent transactivator of the prostate-specific antigen (PSA) promoter. Binds to 5'-GGAT- 3' DNA sequences. May play a role in the regulation of the prostate gland and/or prostate cancer development. Acts as a transcriptional activator for SERPINB5 promoter. {ECO:0000269PubMed:10625666}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in a very restricted set of primarily hormone-regulated epithelial tissues with particularly high expression in the prostate gland. Significantly lower expression is seen in other hormone regulated tissues such as mammary gland, salivary gland, and ovary. Expressed in prostate carcinoma cells. {ECO:0000269PubMed:10625666}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0010454	negative regulation of cell fate commitment
GO:0010455	positive regulation of cell fate commitment
GO:0030154	cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060480	lung goblet cell differentiation
GO:0060576	intestinal epithelial cell development