InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2A

Summary

InnateDB Protein

IDBP-83745.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2A

Protein Name

ubiquitin-conjugating enzyme E2A

Synonyms

HHR6A; MRXS30; MRXSN; RAD6A; UBC2;

Species

Homo sapiens

Ensembl Protein

ENSP00000335027

InnateDB Gene

IDBG-83741 (UBE2A)

Protein Structure

UniProt Annotation

Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. {ECO:0000269PubMed:16337599, ECO:0000269PubMed:20061386}.

Subcellular Localization

Disease Associations

Mental retardation, X-linked, syndromic, Nascimento-type (MRXSN) [MIM:300860]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSN features include dysmorphic facies, hirsutism, skin and nails abnormalities, obesity, speech anomalies and seizures. {ECO:0000269PubMed:16909393, ECO:0000269PubMed:20412111}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0006281	DNA repair
GO:0006301	postreplication repair
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008284	positive regulation of cell proliferation
GO:0009411	response to UV
GO:0033522	histone H2A ubiquitination
GO:0051865	protein autoubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0070979	protein K11-linked ubiquitination