InnateDB Protein
|
IDBP-83931.7
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
PIK3AP1
|
Protein Name
|
phosphoinositide-3-kinase adaptor protein 1
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000360150
|
InnateDB Gene
|
IDBG-83923 (PIK3AP1)
|
Protein Structure
|
|
Function |
Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway. Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1. Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production. Also involved in the activation of PI3K in natural killer cells. May be involved in the survival of mature B-cells via activation of REL. {ECO:0000269PubMed:15893754}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
Expressed in natural killer (NK) cells. {ECO:0000269PubMed:18337558}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
7
[view]
|
Protein-DNA |
3
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
5 [view]
|
|
|
Molecular Function |
Accession |
GO Term |
GO:0036312
|
phosphatidylinositol 3-kinase regulatory subunit binding
|
|
Biological Process |
GO:0014068
|
positive regulation of phosphatidylinositol 3-kinase signaling
|
GO:0034134
|
toll-like receptor 2 signaling pathway
|
GO:0034142
|
toll-like receptor 4 signaling pathway
|
GO:0034154
|
toll-like receptor 7 signaling pathway
|
GO:0034162
|
toll-like receptor 9 signaling pathway
|
GO:0045087
|
innate immune response (InnateDB)
|
GO:0050727
|
regulation of inflammatory response
|
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q6ZUJ8
|
PhosphoSite |
PhosphoSite-Q6ZUJ8
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
118788
|
UniGene |
Hs.310456
|
RefSeq |
|
HUGO |
HGNC:30034
|
OMIM |
607942
|
CCDS |
|
HPRD |
06401
|
IMGT |
|
EMBL |
AK092883
AK125635
AL138765
AL358235
AL591364
BC029917
BX648550
|
GenPept |
AAH29917
BAC03996
BAC86227
CAH71154
CAH73440
CAH73441
CAI13579
CAI13581
CAI13586
|
|
|