InnateDB Protein
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IDBP-84108.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TEAD3
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Protein Name
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TEA domain family member 3
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Synonyms
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DTEF-1; ETFR-1; TEAD-3; TEAD5; TEF-5; TEF5;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000345772
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InnateDB Gene
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IDBG-84102 (TEAD3)
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Protein Structure
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Function |
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269PubMed:18579750, ECO:0000269PubMed:19324877}.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
Preferentially expressed in the placenta.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
15
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
GO:0006355
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regulation of transcription, DNA-templated
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GO:0006357
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regulation of transcription from RNA polymerase II promoter
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GO:0006367
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transcription initiation from RNA polymerase II promoter
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GO:0007565
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female pregnancy
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GO:0010467
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gene expression
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GO:0035329
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hippo signaling
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GO:0045944
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positive regulation of transcription from RNA polymerase II promoter
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Cellular Component |
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PDB ID |
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InterPro |
IPR000818
TEA/ATTS
IPR016361
Transcriptional enhancer factor
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PFAM |
PF01285
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PRINTS |
PR00065
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PIRSF |
PIRSF002603
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SMART |
SM00426
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TIGRFAMs |
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Modification |
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SwissProt |
Q99594
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PhosphoSite |
PhosphoSite-Q99594
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
7005
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UniGene |
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RefSeq |
NP_003205
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HUGO |
HGNC:11716
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OMIM |
603170
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CCDS |
CCDS47414
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HPRD |
04411
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IMGT |
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EMBL |
AL022721
BC027877
BC091488
X94439
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GenPept |
AAH27877
AAH91488
CAA64213
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