InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLIT1

Summary

InnateDB Protein

IDBP-84203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLIT1

Protein Name

slit homolog 1 (Drosophila)

Synonyms

MEGF4; SLIL1; SLIT-1; SLIT3;

Species

Homo sapiens

Ensembl Protein

ENSP00000266058

InnateDB Gene

IDBG-84201 (SLIT1)

Protein Structure

UniProt Annotation

Function

Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions (By similarity). SLIT1 and SLIT2 together seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in adult forebrain. Expressed in fetal brain, lung and kidney. {ECO:0000269PubMed:9813312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0048495	Roundabout binding

Biological Process

GO:0007409	axonogenesis
GO:0007411	axon guidance
GO:0007420	brain development
GO:0008045	motor neuron axon guidance
GO:0021510	spinal cord development
GO:0021772	olfactory bulb development
GO:0022028	tangential migration from the subventricular zone to the olfactory bulb
GO:0022029	telencephalon cell migration
GO:0031290	retinal ganglion cell axon guidance
GO:0033563	dorsal/ventral axon guidance
GO:0040023	establishment of nucleus localization
GO:0048812	neuron projection morphogenesis
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0048846	axon extension involved in axon guidance
GO:0048853	forebrain morphogenesis
GO:0050919	negative chemotaxis
GO:0051964	negative regulation of synapse assembly

Cellular Component

GO:0005615

extracellular space

Protein Structure and Domains

PDB ID

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR000742 Epidermal growth factor-like domain
IPR001611 Leucine-rich repeat
IPR001791 Laminin G domain
IPR001881 EGF-like calcium-binding domain
IPR003591 Leucine-rich repeat, typical subtype
IPR003645 Follistatin-like, N-terminal
IPR006207 Cystine knot, C-terminal
IPR008985 Concanavalin A-like lectin/glucanases superfamily

PFAM