InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LRRFIP1

Summary

InnateDB Protein

IDBP-84324.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LRRFIP1

Protein Name

leucine rich repeat (in FLII) interacting protein 1

Synonyms

FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; TRIP;

Species

Homo sapiens

Ensembl Protein

ENSP00000244815

InnateDB Gene

IDBG-84322 (LRRFIP1)

Protein Structure

UniProt Annotation

Function

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. {ECO:0000269PubMed:10364563, ECO:0000269PubMed:14522076, ECO:0000269PubMed:16199883, ECO:0000269PubMed:19265123, ECO:0000269PubMed:9705290}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9671805, ECO:0000269PubMed:9705290}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	25 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0008150	biological_process
GO:0032481	positive regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0045892	negative regulation of transcription, DNA-templated