InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RABGAP1

Summary

InnateDB Protein

IDBP-84362.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RABGAP1

Protein Name

RAB GTPase activating protein 1

Synonyms

GAPCENA; TBC1D11;

Species

Homo sapiens

Ensembl Protein

ENSP00000362751

InnateDB Gene

IDBG-84360 (RABGAP1)

Protein Structure

UniProt Annotation

Function

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase- anaphase transition. {ECO:0000269PubMed:10202141, ECO:0000269PubMed:16395330}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000269PubMed:10202141}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10202141}. Note=Predominantly cytosolic but also associated with the centrosome. {ECO:0000269PubMed:10202141}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.

Experimentally validated
Total	20 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005096	GTPase activator activity
GO:0005097	Rab GTPase activator activity
GO:0005515	protein binding
GO:0015631	tubulin binding

Biological Process

GO:0007049	cell cycle
GO:0032313	regulation of Rab GTPase activity
GO:0032851	positive regulation of Rab GTPase activity
GO:0043547	positive regulation of GTPase activity