Version 5.4
Homo sapiens Protein: FRAT1
Summary
InnateDB Protein IDBP-84515.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FRAT1
Protein Name frequently rearranged in advanced T-cell lymphomas
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000360060
InnateDB Gene IDBG-84511 (FRAT1)
Protein Structure
UniProt Annotation
Function Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis. {ECO:0000269PubMed:12556519}.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR008014 Glycogen synthase kinase-3 binding protein
PFAM PF05350
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92837
PhosphoSite PhosphoSite-Q92837
TrEMBL
UniProt Splice Variant
Entrez Gene 10023
UniGene Hs.721422
RefSeq NP_005470
HUGO HGNC:3944
OMIM 602503
CCDS CCDS7455
HPRD 03935
IMGT
EMBL AB074890 AL355490 BC034476 U58975
GenPept AAB97096 AAH34476 BAB86352 CAI40773

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca