Version 5.4
Homo sapiens Protein: TRAF3IP1
Summary
InnateDB Protein IDBP-84550.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRAF3IP1
Protein Name TNF receptor-associated factor 3 interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000362424
InnateDB Gene IDBG-84548 (TRAF3IP1)
Protein Structure
UniProt Annotation
Function Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. {ECO:0000269PubMed:10791955, ECO:0000269PubMed:12812986, ECO:0000269PubMed:12935900}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:12935900}. Cell projection, cilium {ECO:0000250}. Note=Microtubules.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:12935900}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
Experimentally validated
Total 69 [view]
Protein-Protein 69 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
Biological Process
GO:0021532 neural tube patterning
GO:0031076 embryonic camera-type eye development
GO:0032688 negative regulation of interferon-beta production
GO:0035050 embryonic heart tube development
GO:0036342 post-anal tail morphogenesis
GO:0042384 cilium assembly
GO:0042733 embryonic digit morphogenesis
GO:0050687 negative regulation of defense response to virus
GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
Cellular Component
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005856 cytoskeleton
GO:0005929 cilium
GO:0005930 axoneme
GO:0030992 intraciliary transport particle B
GO:0036064 ciliary basal body
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TDR0
PhosphoSite PhosphoSite-Q8TDR0
TrEMBL
UniProt Splice Variant
Entrez Gene 26146
UniGene Hs.631898
RefSeq NP_056465
HUGO HGNC:17861
OMIM 607380
CCDS CCDS33415
HPRD 09571
IMGT
EMBL AC012485 AF230877 AF242456 AL080153 BC059174 CH471063
GenPept AAF76984 AAH59174 AAL90444 AAX88977 CAB45744 EAW71157

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca