InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TNFRSF18

Summary

InnateDB Protein

IDBP-84588.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNFRSF18

Protein Name

tumor necrosis factor receptor superfamily, member 18

Synonyms

AITR; CD357; GITR; GITR-D;

Species

Homo sapiens

Ensembl Protein

ENSP00000328207

InnateDB Gene

IDBG-84584 (TNFRSF18)

Protein Structure

UniProt Annotation

Function

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.

Disease Associations

Tissue Specificity

Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005031	tumor necrosis factor-activated receptor activity
GO:0005515	protein binding

Biological Process

GO:0006915	apoptotic process
GO:0007165	signal transduction
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)