InnateDB Protein
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IDBP-84590.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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TNFRSF18
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Protein Name
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tumor necrosis factor receptor superfamily, member 18
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Synonyms
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AITR; CD357; GITR; GITR-D;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000368567
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InnateDB Gene
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IDBG-84584 (TNFRSF18)
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Protein Structure
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Function |
Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.
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Subcellular Localization |
Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.
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Disease Associations |
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Tissue Specificity |
Expressed in lymph node, peripheral blood leukocytes and weakly in spleen.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
10
[view]
|
Protein-Protein |
10
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005031
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tumor necrosis factor-activated receptor activity
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GO:0005515
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protein binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001368
TNFR/NGFR cysteine-rich region
IPR022318
Tumour necrosis factor receptor 18
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PFAM |
PF00020
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PRINTS |
PR01968
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PIRSF |
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SMART |
SM00208
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Y5U5
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
8784
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UniGene |
Hs.212680
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RefSeq |
NP_683700
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HUGO |
HGNC:11914
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OMIM |
603905
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CCDS |
CCDS30552
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HPRD |
04879
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IMGT |
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EMBL |
AF117297
AF125304
AF241229
AL162741
AY358877
BC152381
BT019531
BT019532
CH471183
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GenPept |
AAD19694
AAD22635
AAF63506
AAI52382
AAQ89236
AAV38338
AAV38339
CAI23246
CAI23247
EAW56282
EAW56283
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