InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LHX2

Summary

InnateDB Protein

IDBP-84684.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LHX2

Protein Name

LIM homeobox 2

Synonyms

hLhx2; LH2;

Species

Homo sapiens

Ensembl Protein

ENSP00000362717

InnateDB Gene

IDBG-84682 (LHX2)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001076	RNA polymerase II transcription factor binding transcription factor activity
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001843	neural tube closure
GO:0006366	transcription from RNA polymerase II promoter
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007498	mesoderm development
GO:0009953	dorsal/ventral pattern formation
GO:0021537	telencephalon development
GO:0021772	olfactory bulb development
GO:0021978	telencephalon regionalization
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0030182	neuron differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048646	anatomical structure formation involved in morphogenesis
GO:0048675	axon extension
GO:0060041	retina development in camera-type eye
GO:2000678	negative regulation of transcription regulatory region DNA binding