Version 5.4
Homo sapiens Protein: AURKAIP1
Summary
InnateDB Protein IDBP-85285.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AURKAIP1
Protein Name aurora kinase A interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000319778
InnateDB Gene IDBG-85279 (AURKAIP1)
Protein Structure
UniProt Annotation
Function May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
Subcellular Localization Mitochondrion {ECO:0000269PubMed:23908630}. Nucleus {ECO:0000269PubMed:23908630}.
Disease Associations
Tissue Specificity Ubiquitously expressed and especially highly expressed in heart, skeletal muscle and testis.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045839 negative regulation of mitosis
GO:0045862 positive regulation of proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0043231 intracellular membrane-bounded organelle
Protein Structure and Domains
PDB ID
InterPro IPR013177 Domain of unknown function DUF1713, mitochondria
PFAM PF08213
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NWT8
PhosphoSite PhosphoSite-Q9NWT8
TrEMBL A0A024R0F0
UniProt Splice Variant
Entrez Gene 54998
UniGene
RefSeq NP_001120702
HUGO HGNC:24114
OMIM 609183
CCDS CCDS25
HPRD 16457
IMGT
EMBL AK000615 AL139287 BC022808 BC062333 CH471183
GenPept AAH22808 AAH62333 BAA91289 CAI23191 EAW56218 EAW56219

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca